ICJEM
Intercontinental Journal of Emergency Medicine

The Intercontinental Journal of Emergency Medicine aims to publish issues related to all fields of emergency medicine and all specialties involved in the management of emergencies in the hospital and prehospital environment of the highest scientific and clinical value at an international level and accepts articles on these topics.

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Original Article
The significance of Systemic Immune-Inflammation Index, pan-immune-inflammation value, and Systemic Inflammation Response Index in the etiopathogenesis of acute pancreatitis
Abstract
Aims: Acute pancreatitis (AP) is an inflammatory disease with a wide clinical spectrum ranging from mild self-limited inflammation to severe life-threatening complications. Early identification of disease severity is essential for appropriate clinical management. Recently, novel inflammatory indices derived from routine hematological parameters, including the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Pan-Immune Inflammation Value (PIV), have been proposed as potential biomarkers reflecting systemic inflammatory status. This study aimed to evaluate the diagnostic and prognostic value of SII, SIRI, and PIV in patients with acute pancreatitis.
Methods: This retrospective observational study included 101 patients diagnosed with acute pancreatitis and 118 healthy controls. Demographic, clinical, and laboratory data were obtained from the hospital electronic medical record system. Laboratory parameters including white blood cell count, neutrophils, lymphocytes, platelets, C-reactive protein, serum amylase, and lipase were analyzed. SII, SIRI, and PIV values were calculated using standard formulas derived from peripheral blood cell counts. Group comparisons were performed using appropriate statistical tests, and receiver operating characteristic (ROC) curve analysis was conducted to determine the diagnostic performance of inflammatory indices. A p value <0.05 was considered statistically significant.
Results: Serum amylase, lipase, WBC count, neutrophil count, NLR, CRP, and inflammatory indices (SII, SIRI, and PIV) were significantly higher in patients with acute pancreatitis compared with the control group (p<0.05). ROC curve analysis demonstrated that these indices had strong diagnostic performance. Among the evaluated parameters, PIV showed the highest diagnostic accuracy with an area under the curve (AUC) of 0.895, followed by SIRI (AUC=0.890), SII (AUC=0.831), and NLR (AUC=0.823).
Conclusion: SII, SIRI, and PIV are practical and cost-effective biomarkers derived from routine laboratory parameters that may aid in the early diagnosis and prognostic evaluation of acute pancreatitis. These indices may help clinicians assess systemic inflammatory response and identify high-risk patients in the early stage of the disease. Further prospective multicenter studies are needed to confirm their clinical utility.

Keywords : Acute pancreatitis, Systemic Immune-Inflammation Index, Systemic Inflammation Response Index, Pan-Immune Inflammation Value, inflammatory biomarkers, prognosis

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Article available in :
Volume 4, Issue 3, 2026
Page : 48-52
https://doi.org/10.51271/ICJEM-0079
Article Information
Received : 15 Mar 2026
Accepted : 02 May 2026
Published : 19 Eyl 2026
Corresponding Author :

Ali Kablan: Department of Emergency Medicine, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : Kablan A, Avcıoğlu G, Çelikel E. The significance of Systemic Immune-Inflammation Index, pan-immune-inflammation value, and Systemic Inflammation Response Index in the etiopathogenesis of acute pancreatitis. Intercont J Emerg Med. 2026;4(3):48-52. doi:10.51271/ICJEM-0079

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