ICJEM

The Intercontinental Journal of Emergency Medicine aims to publish issues related to all fields of emergency medicine and all specialties involved in the management of emergencies in the hospital and prehospital environment of the highest scientific and clinical value at an international level and accepts articles on these topics.

EndNote Style
Index
Original Article
The effect of neutrophil lymphocyte ratio and other biochemical parameters on mortality in cancer patients admitted to the emergency department
Aims: To investigate the effectiveness of the neutrophil/lymphocyte ratio and other biochemical parameters in predicting mortality in oncology patients with cancer admitted to the emergency department.
Methods: This was a retrospective, observational, single-center study. The study period included a two-year period from January 2014 to December 2015. Demographic data, cancer history and blood tests, emergency department diagnoses, blood parameters evaluated in the emergency department, discharge, and mortality status of the patients were recorded in the data form. The APACHE 2 and SOFA scores of all patients were also calculated. Patients whose data could not be reached were excluded from the study. p<0.05 was considered statistically significant.
Results: A total of 180 patients were included in the study. The mean age of the survivor group was 66.4±10.752 years, while the mean age of the non-survivor group was 65.18±13 years. The mean neutrophil/lymphocyte (NLR) ratio of the non-survivor group was 1.0288±11.3, while the NLR of the survivor group was 4.400±3.563. (p<0.05) The mean lactate ratio of the non-survivor group was 2.60±3.384, while the mean lactate ratio of the survivor group was 1.36±1. 090. (p<0.05) When survivor and non-survivor patient groups were compared, a statistically significant difference was observed in mean white blood cell count, neutrophil count, hemoglobin, hematocrit, and blood urea nitrogen (BUN) values. (p<0.05)
Conclusion: According to the results of this study, NLR, elevated white blood cell and neutrophil values, decreased hemoglobin and hematocrit, and elevated BUN and lactate levels seem to be predictors of mortality during emergency admissions in cancer patients.


1. Gerstberger S, Qingwen J, Karuna G. Metastasis. Cell 186.8 2023;186.8:1564-1579.
2. Altınbaş M, Hepşen S. Kanser hastalarının &ouml;l&uuml;m nedenleri vesağkalımı etkileyen fakt&ouml;rler. Sakarya Med J. 2015;5(1):5-9 doi:10.5505/sakaryamj.2015.33608.
3. Einsele H, Hebart H, Bokemeyer C, et al. Infektiologische Notfaelle beiPatienten mit Tumorerkrankungen. Onkologe. 1998;5:1075-1082.
4. Tamhane UU, Aneja S, Montgomery D, et al. Association betweenadmission neutrophil to lymphocyte ratio and outcomes in patientswith acute coronary syndrome. Am J Cardiol. 2008;102:653-657.
5. Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an elevatedneutrophil to lymphocyte ratio in predicting long-term mortality afterpercutaneous coronary intervention. Am J Cardiol. 2006;97:993-996.
6. Dentali F, Nigro O, Squizzato A, et al. Impact of neutrophils tolymphocytes ratio on major clinical outcomes in patients with acutecoronary syndromes: A systematic review and meta-analysis of theliterature. Int J Cardiol 2018;266:31-37.
7. Blake-Mortimer JS, Sephton SE, Carlson RW, et al. Cytotoxic Tlymphocyte count and survival time in women with metastatic breastcancer. Breast J 2004;10:195-199.
8. Kov&aacute;cs AR, Sulina A, Kov&aacute;cs KS, et al. Prognostic significance ofpreoperative NLR, MLR, and PLR values in predicting the outcomeof primary cytoreductive surgery in serous epithelial ovarian cancer.Diagnostics 2023;4;13(13):2268.
9. Knaus WA, Draper EA, Wagner DP. APACHE II: a severity of diseaseclassification system. Crit Care Med 1985;13:29-818.
10. Husain FA, Martin MJ, Mullenix PS, et al. Serum lactate and base deficitas predictors of mortality and morbidity. Am J Surg. 2003;185:485-491.
11. Holtfreter B, Bandt C, Kuhn S-O, et al. Serum osmolality and outcomein intensive care unit patients. Acta Anaesthesiol Scand. 2006;50:970-977.
12. Fuller BM, Dellinger RP. Opinion in Critical Care. Division of CriticalCare. 2012;18(3):267-272.
13. Jilma B, Blann A, Pernerstorfer T, et al. Regulation of adhesionmolecules during human endotoxemia. No acute effects of aspirin. AmJ Respir Crit Care Med. 1999;159:63-587.
14. Dionigi R, Dominioni L, Benevento A, et al. Effects of surgical traumaof laparoscopic vs. Open cholecystectomy. Hepatogastroenterology.1994;41:76-471.
15. O&rsquo;Mahony JB, Palder SB, Wood JJ, et al. Depression of cellularimmunity after multiple trauma in the absence of sepsis. J Trauma.1984;24:75-869.
16. Zahorec R. Ratio of neutrophil to lymphocyte counts&mdash;Rapid andsimple parameter of systemic inflammation and stress in critically ill.Bratisl Lek Listy. 2001;102:5-14.
17. Tamhane UU, Aneja S, Montgomery D, et al. Association betweenadmission neutrophil to lymphocyte ratio and outcomes in patientswith acute coronary syndrome. Am J Cardiol. 2008;102:653-657.
18. Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an elevatedneutrophil to lymphocyte ratio in predicting long-term mortality afterpercutaneous coronary intervention. Am J Cardiol. 2006;97:396-396.
19. Chen C, Cong BL, Wang M, et al. Neutrophil to lymphocyte ratio asa predictor of myocardial damage and cardiac dysfunction in acutecoronary syndrome patients. Integr Med Res, 2018;7(2):192-199.
20. Blake-Mortimer JS, Sephton SE, Carlson RW, et al. Cytotoxic Tlymphocyte count and survival time in women with metastatic breastcancer. Breast J. 2004;10:195-199.
21. &Ouml;zt&uuml;rk S, Erdem A, &Ouml;zl&uuml; MF, et al. Assessment of the neutrophil tolymphocyte ratio in young patients with acute coronary syndromes.Arch Turk Soc Cardiol. 2013;41:284-289.
22. Kap&ccedil;ı M, T&uuml;rkdoğan KA, Duman A, et al. Biomarkers in the diagnosisof acute appendicitis. J Clin Exp Invest. 2014;5:250-255.
23. Kahramanca S, Ozgehan G, Seker D, et al. Neutrophil-to-lymphocyteratio as a predictor of acute appendicitis. Ulus Travma Acil CerrahiDerg. 2014;20:19-22.
24. Tuomisto AE, M&auml;kinen MJ, V&auml;yrynen JP (2019). Systemic inflammationin colorectal cancer: Underlying factors, effects, and prognosticsignificance. World J Gastroenterol 2019;25(31):4383.
25. Miyata H, Yamasaki M, Kurokawa Y, et al. Prognostic value of aninflammation-based score in patients undergoing pre-operativechemotherapy followed by surgery for esophageal cancer. Exp TherMed. 2011;2:879-885.
26. Celikbilek M, Dogan S, Ozbakır O, et al. Neutrophil-lymphocyte ratioas a predictor of disease severity in ulcerative colitis. J Clin Lab Anal.2013;27:6-72.
27. Imtiaz F, Shafique K, Mirza SS, et al. Neutrophil Lymphocyte ratio asa measure of systemic inflammation in prevalent Chronic diseases inAsian population. Int Arch Med. 2012;5:2.
28. Proctor MJ, Morrison DS, Talwar D, et al. A comparison of inflammation-based prognostic Scores in patients with cancer. A Glasgow InflammationOutcome Study. Eur J Cancer. 2011;47:2633-2641.
29. Raungkaewmanee S, Tangjitgamol S, Manusirivithaya S, et al. Plateletto lymphocyte ratio as a prognostic factor for epithelial ovarian cancer.J Gynecol Oncol. 2012;23:265-273.
30. Akpınar CK, Kocaturk O, Aykac O, et al. Can C-reactive protein/albumin ratio be a prognostic factor in acute stroke patients undergoingmechanical thrombectomy? Clin Neurol Neurosurg. 2023;231:107856.
Volume 1, Issue 4, 2023
Page : 67-70
_Footer