ICJEM
Intercontinental Journal of Emergency Medicine

The Intercontinental Journal of Emergency Medicine aims to publish issues related to all fields of emergency medicine and all specialties involved in the management of emergencies in the hospital and prehospital environment of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Investigation of changes in MDH enzyme activity in epilepsy
Abstract
Aims: Epilepsy is one of the most common neurological diseases. It is classified into three groups: focal onset, generalized onset and unclassifiable. A seizure type is difficult to determine. The malate dehydrogenase (MDH) enzyme has a critical role in the excitability of the brain, and it has been reported that recurrent seizures are seen when its regulation is disturbed. We investigated the contribution of MDH enzyme levels as a biomarker to seizure classification.
Methods: Our study was conducted prospectively by patients who were admitted to the emergency department of our hospital within a six-month period. Included in the study were 65 patients diagnosed with epilepsy, according to the International League Against Epilepsy (ILAE) classification. The patients were divided into two groups according to seizure type: focal onset and generalized onset. They were compared in terms of enzyme activity.
Results: The MDH values of the patients with primary epilepsy were found to be 105.94±111.43 and those with secondary epilepsy were 81.03±121.59 (p=0.141). The same test was used to compare the distribution of MDH values between seizure type groups. The MDH value was 47.56±38.65 in patients with focal-onset epilepsy and 109.76±128.44 in patients with generalizedonset epilepsy. A statistically significant difference was observed in the comparisons between the groups (p= 0.031)
Conclusion: Our results reveal the potential of MDH as a biomarker that can be used in epilepsy. In addition, the statistically significant difference between focal-onset and generalized-onset epilepsy indicates that it can be a usable biomarker in seizure classification. MDH enzyme level has a cut-off value of 109.76±128.44 IU/L strongly underlines that it should be used in the diagnosis.

Keywords : Epilepsy, malate dehydrogenase, generalized-onset

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Article available in :
Volume 1, Issue 1, 2023
Page : 1-3
https://doi.org/10.51271/ICJEM-0001
Article Information
Received : 15 Mar 2023
Accepted : 27 Mar 2023
Published : 30 Mar 2023
Corresponding Author :

Bahadır Taşlıdere: Department of Emergency Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey

[email protected]
Citation : Taşlıdere B, Güven EC, Oflaz Güven B, Gülen B. Investigation of changes in MDH enzyme activity in epilepsy. Intercont J Emerg Med. 2023;1(1):1-3.

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